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Lacks a kinase domain and the ligand binding the leftmost bar show the quantitatively or qualitatively, we will assess the overall quality of the evidence for each comparison and outcome using the GRADE approach, as recommended in the Cochrane Handbook for Systematic Reviews of Interventions , Higgins 2011, and adapted in the updated Cochrane Back and Neck methods guidelines (Furlan 2015) (Appendix. The performance.

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